Very much so. GIF以256色色调色盘封盖,单位(上/下)透明,不部分阿尔法,这就是为什么照片带和带的抖动. That determines both the headroom available and whether the saving costs you anything in fidelity.
Is there anything specific to GIF I should know before compressing?
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Yes — 调色盘在整个动画中共享, 所以对一个框架的任何修改 都要根据每个框架的颜色来谈判 每一个框架需要的颜色. It is worth knowing before you overwrite an original you might need again.