Very much so. TIFF是档案容器:无损LZW或DEFLATE、16位/每通道深度、CMYK和一个文件中的多页. That determines both the headroom available and whether the saving costs you anything in fidelity.
Is there anything specific to TIFF I should know before compressing?
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Yes — 单一的TIFF可以保持几页和16位/每频道数据,因此,工具必须决定是按第一页还是按所有页采取行动. It is worth knowing before you overwrite an original you might need again.